Rinsing agent tabs, compressed granules from spray agglomeration in the fluid bed
Fluid bed spray agglomeration as a perfect alternative to direct compression of powder mixtures
In the production of tablets, direct compression of the powder mixture is often not possible.
Weak cohesive forces between powder particles often result in insufficient tablet strength. Also, due to flow-inhibiting adhesive forces, fine powders exhibit poor flowability, which can result in inadequate dosing accuracy when filling the dies. If highly potent active ingredients are present as fine powders, dust formation makes safe powder handling difficult. If different particle sizes are combined in a powder mixture, segregation processes can counteract a trouble-free tableting process with consistent product quality.
Consequently, the powder properties are decisive for the success of tabletting and the tablet properties that can be achieved.
Spray agglomeration based on fluid bed technology solves all these problems. By spraying a binder solution onto powder particles, they can be glued together, thus increasing particle size and reducing fines content. Formulation ingredients, such as active ingredients, can also be sprayed on with the binder solution and thus homogeneously distributed. By establishing individual process and formulation parameters, agglomerates with defined properties such as particle size, shape or bulk density can be produced. In the process, flowability is improved, segregation of different powder fractions is avoided, and the dust content is reduced, thereby specifically influencing tablet properties, such as disintegration characteristics or dissolution behavior, and ensuring consistently excellent tablet quality.
At the Glatt Technology Center in Weimar, we work with you to determine the optimum process conditions for your product in feasibility trials for product development. Various laboratory facilities and comprehensive analytical equipment are available for this purpose. On our pilot plants, we optimize the process and scale it up reliably to a stable and economical production scale. The results from this form the basis for the design and construction as well as the erection of your fluid bed or spouted bed plant, tailored to your requirements. As an alternative to our own process technology, we offer you the outsourcing of your production by means of contract manufacturing at Glatt.
Further information can also be found in the following publications, among others: