Microencapsulation for improved bioavailability: So that important nutrients can be taken up and absorbed by the body
While this issue is the most essential for the formulation of pharmaceutical dosage forms, as it determines the efficacy of the drug, studies on the uptake of dietary supplements are only just beginning. However, water-insoluble substances cannot be absorbed by the body and must therefore be converted into a soluble micellar structure. In liquid form, these formulations have a limited shelflife stability, so a drying step follows, which produces a wide variety of product forms ranging from readily mixable powders to dust-free, easily soluble granules or compact, defined pellets. The moderate and precisely controllable process temperature in the fluidized bed or spouted bed is particularly suitable for sensitive active ingredients.
Coenzyme Q10, curcuma or similar substances are typical candidates for improving bioavailability. The process steps required for this can be completely tested from micelle formation to the dry product.
Whether aqueous, organic-based coating solutions, fats or melts, at the Glatt Technology Center in Weimar, we work with you to determine the optimum process conditions for your product in feasibility trials for product development. Various laboratory facilities and comprehensive analytical equipment are available for this purpose. On our pilot plants, we optimize the process and scale it up reliably to a stable and economical production scale. The results from this form the basis for the design and construction as well as the erection of your fluid bed or spouted bed plant, tailored to your requirements. As an alternative to our own process technology, we offer you the outsourcing of your production by means of contract manufacturing at Glatt.
From development to production readiness—microencapsulation of hydrophobic active ingredients and the specific challenges involved in formulation and scale-up.
Meet our colleagues at the B2B meeting and let’s work together to find solutions to your challenges.
Copyright by Glatt
Copyright: Glatt
Copyright by Glatt