To commercialize next-generation cathode materials a lot of different synthesis methods need to be researched and evaluated regarding the attainable electrochemical properties of the materials on one hand, and the scalability of the process on the other. For the high voltage LiNi0.5Mn1.5O4 cathode material especially the degradation of the material during cycling needs to be investigated for different scales and techniques. LiNi0.5Mn1.5O4 (LNMO) was synthesized using two different methods in different scales: lab-scaled spray drying and pilot-scaled gas pulse drying.