Lactobacilli, layering and enteric protective coating
Drying, encapsulation and immobilization of microorganisms
The health-promoting effect of probiotics has been proven by various studies in recent years and is undisputed. The multitude of dietary supplements but also enriched foods is a sign of this. The aim of all these products is the colonization of microorganisms in the intestine to support the existing intestinal flora. The efficiency of the products, especially the number of surviving microorganisms, is crucial for this. The diversity of bacterial strains, their temperature sensitivity and the specific requirements of their milieu rarely allow standard solutions. After fermentation, the organisms must be converted to a storage-stable state – usually by freeze-drying. Sometimes other drying methods are successful.
The drying and stabilization of microorganisms in the fluidized bed was investigated in a case study using the example of a lactobacillus strain. The result proves that only a close interaction of formulation, process control and plant design is target-oriented.
With its spouted bed technology, Glatt has developed and patented a special process for encapsulating and immobilizing microorganisms. The excellent heat and mass transfer conditions enable gentle drying of the microorganisms.
To improve the survival rate, the formulation can be enriched with various protective substances and prebiotics. It is possible to enclose the product directly afterwards with an enteric coating.
At the Glatt Technology Center in Weimar, we work with you to determine the optimum process conditions for your product in feasibility trials for product development. Various laboratory facilities and comprehensive analytical equipment are available for this purpose. On our pilot plants, we optimize the process and scale it up reliably to a stable and economical production scale. The results from this form the basis for the design and construction as well as the erection of your fluid bed or spouted bed plant, tailored to your requirements. As an alternative to our own process technology, we offer you the outsourcing of your production by means of contract manufacturing at Glatt.
Lactobacilli, layering, 10 µm, 1500-fold
Lactobacilli, layering, 20 µm, 5000-fold
Lactobacilli, enteric coating, 20 µm, 500-fold
Lactobacilli, enteric coating, 10 µm, 5000-fold
Poster:
A continuous process for drying, stabilization and coating of probiotic micro-organisms unsing the Glatt ProCell® process unit
An analytical method to measure capsule integrity of micro encapsulated priobiotic micro organisms. The Glatt ProCell® apparatus allows drying of micro organism with higher temperatures than conventional air drying. The carrier material used in these trials, malto dextrin and whey powder, have appeared to provide protection for shelf life. The addition of prebiotic fibers into the capsule wall provides interesting symbiotic effects.
Authors:
Michael Jacob, Glatt Ingenieurtechnik GmbH, Weimar / DE
Jean-Antoine Meiners, MCC s.a. Micor-encapsulation technology / CH
Jean-Michael Pommet, Ncapsolutions, F
Further information on this topic and related topics can also be found in the following publications:
Link to: Protecting sensitive substances effectively – Particle design by fluidized bed and spouted bed processes
Copyright: Konradin-Verlag Robert Kohlhammer GmbH
Published article: ‘Protecting sensitive substances effectively – Particle design by fluidized bed and spouted bed processes’ PDF, German
Link to: Customized properties – drying and stabilization of microorganisms by fluid bed and spouted bed technology
Copyright: HĂĽthig GmbH
Published article: ‘Customized properties – drying and stabilization of microorganisms by fluid bed and spouted bed technology’ PDF, German
Link to: Hot-melt applications for the food and beverage industry – How to safely stabilize vitamins and probiotics
Copyright: Hoskins & Fall Publishing
Published article: ‘Hot-melt applications for the food and beverage industry – How to safely stabilize vitamins and probiotics’ PDF, English
Link to: Enhancing product properties with fluid bed and spouted bed technologies
Copyright: J.Latka Verlag GmbH
Published article: ‘Enhancing product properties with fluid bed and spouted bed technologies’ PDF, English
Link to: Fluidized bed solutions for optimized ingredient production
Copyright: B5 S.r.l.
Published article: ‘Fluidized bed solutions for optimized ingredient production’ PDF, English
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